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Project partners

ACREO SWEDISH ICT AB (ACREO)

Description of organisation

Acreo Swedish ICT AB is one of the leading research institutes in Europe within the field of electronics, optics, communication techniques and sensor systems. Acreo works to facilitate the commercialization of research and to strengthen collaboration between industry and academic research and the research is performed in R&D projects together with an industry partner or in projects funded by a financier such as EU. The types of assignments are ranging from feasibility studies, long term research projects, prototyping and small scale production, to verification and testing. We also support small and medium sized companies with technology transfer, business networks and financial advice through Acreos business services. Acreo is a part of Swedish ICT and has 165 employees located in Kista (Head office), Norrköping, Hudiksvall and Göteborg.

Role(s) in the NanoMag project

Acreo is Scientific Coordinator of the NanoMag project. Acreo will carry out magnetic analysis regarding medium and high field AC susceptometry (magnetic susceptibility vs. frequency), magnetic modeling and magnetic separation experiments of the magnetic nanoparticle systems. As in the role of Scientific Coordinator Acreo is also participant in WP1 – WP7.

BUNDESANSTALT FUER MATERIALFORSCHUNG UND PRUEFUNG (BAM)

Description of organisation

BAM is the German Federal Institute for Materials Research and Testing. Its competences are to improve safety in technology and chemistry through research and development, testing, analysis, approvals, advice and information. Within the interconnected fields of materials, chemistry, environment and safety BAM advises the Federal Government as well as industry and plays a vital role in the development of new techniques. BAM has profound knowledge and experience in small-angle X-ray scattering (SAXS) coupled online with asymmetrical flow field-flow fractionation (A4F) and dynamic light scattering (DLS) for the investigation of nanostructures in the 1 to 100 nm range. BAM uses SAXS in combination with commercial X-ray tubes and also with hard X-ray synchrotron radiation at its own beamline at the Berlin Electron Synchrotron BESSY.

Role(s) in the NanoMag project

BAM will carry out asymmetrical flow field flow fractionation (A4F) coupled online with SAXS and DLS of the magnetic nanoparticle systems. Validation of A4F-SAXS and A4F-SAXS-DLS couplings as traceable methods for determination of size distributions of magnetic nanoparticle will be studied. Contribution to standardization bodies like DIN, CEN and ISO will also be carried out by BAM.

CHALMERS TEKNISKA HOEGSKOLA AB (CHALMERS)

Description of organisation

There is a long tradition of TE and SE stemming back from the 9 0’s at the Department of pplied Physics at CTH. The research activities are currently led by Professor Eva Olsson and the Eva Olsson Group, which has a staff of 3 senior scientists, 2 post-docs and 6 PhD students. The research within the field relates to developing and improving a fundamental understanding of the fine-scale microstructure of technologically important materials, its manipulation and importance in determining the properties of materials. The majority of the on-going projects are related to nanoscale structures and a few of these have a direct focus towards nanoparticles, for example in the fields of catalysis and nano safety. The profile of the activities is characterised by analytical TEM and in situ dynamic studies in TEM and SEM. New analysis techniques are being adapted and developed. It should be noted that techniques of in-situ scanning probe microscopy (SPM) including atomic force microscopy (AFM) and scanning tunnelling microscopy (STM) in the TEM have been developed with the Eva Olsson Group at Chalmers. The electron microscopy lab is part of the unit for research infrastructure at the Department of Applied Physics, Chalmers University of Technology. The lab currently hosts 3 TEMs, 2 SEMs (of which one is an Environmental SEM – ESEM) and 2 Focussed Ion Beam work stations (FIB-SEM). The Titan TEM, which was installed in 2007, includes the two major and most recent breakthroughs since the transmission electron microscope was introduced in 1932. The monochromator for electron beam energy filtering enables high energy resolution electron energy loss spectroscopy (EELS) in the TEM. An energy resolution of 0.11 eV has been measured at 300 kV in the Titan at Chalmers. The corrector for spherical aberration of the magnetic lenses enables the formation of an electron beam with a diameter down to 0.7 Å. The microscope gives access to information about, for example, band gap, plasmons, bonding and coordination on the subnanometer scale. The Chalmers electron microscopy infrastructure is also a partner of ESTEEM2 (Enabling Science and Technology through European Electron Microscopy), which is a European integrated infrastructure of electron microscopy facilities. It provides access for academia and industry to the most advanced characterisation techniques on the nanoscale.

Role(s) in the NanoMag project

Chalmers will carry out Transmission Electron Microscopy (TEM), High Resolution Electron Microscopy (HRTEM) and Scanning Electron Microscopy (SEM) of the magnetic nanoparticle systems.

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

Description of organisation

The Agencia Estatal Consejo Superior de Investigaciones Científicas (CSIC) is the largest public research organization in Spain, and it is distinguished by its multidisciplinary nature, approaching all knowledge areas, from basic research to top-most advanced technological developments. CSIC is responsible of 20% of international scientific publications of Spain and the 30% of the Spanish European patents. It has a staff of more than 13500 employees, among them 3.500 scientist and about 4000 pre and postdoctoral researchers. The CSIC has 126 institutes or centres distributed throughout Spain, including 50 Joint Research Units with universities or other research institutions. There is also a delegation in Brussels. The Institute of Materials Science in Madrid (ICMM) belongs to the Area of Science and Technology of Materials, one of the eight Areas in which the CSIC divides its research activities (http://www.icmm.csic.es). Its mission is to create new fundamental and applied knowledge in materials of high technological impact, their processing and their transfer to the productive sectors at local, national and European scales (the true value of materials is in their use), the training of new professionals, and the dissemination of the scientific knowledge. It has around 400 employees, among them 105 scientists and about 125 pre and postdoctoral researchers and a budget of 2 € in 20 2. The Nanocrystals and Chemistry Group at the Institute of Material Science of Madrid has a main objective on the preparation of various kinds of nanoparticles such as magnetic oxides or metals with different morphologies. Modern approaches like decomposition in organic media or laser and spray pyrolysis of metal organic compounds are setup in our lab. Further modification of nanoparticles is a pre-requisite for almost any application. Chemisorbed organic monolayers and/or additional inorganic shells on the nanocrystal core are tested. The goal of the modification is to introduce certain properties to the core-nanoparticles, such as colloidal stability in water, thermal stability, functional groups or new properties. The research activities of this group concentrate on four fields: The preparation of nanomaterials, primarily nanoparticles, and the modification of nanomaterials by doping or coating, the preparation of colloidal suspensions and the characterisation of them. All areas are closely connected to give new insights in the properties of nanomaterials and/or lead to novel applications in biotechnology and biomedicine fields such as contrast agents for MRI, magnetic heating and drug delivery.

Role(s) in the NanoMag project

CSIC will prepare magnetic nanoparticle systems by different synthesis routes. CSIC will modify their properties by coating and basic characterization of their structural and colloidal properties. CSIC is also WP leader of WP3.

DANMARKS TEKNISKE UNIVERSITET (DTU)

Description of organisation

DTU provides a stimulating research environment with more than 600 researchers working within areas of nanotechnology. DTU offers a comprehensive course plan with theoretical and experimental courses that allows students with various scientific backgrounds to learn about the different facets of micro and nanotechnology. DTU has a long track record on IPR handling and administrative support to national and European projects. DTU has generated 10 start-up and spin-off companies. The DTU partners in the project span two institutes at DTU, Department of Physics (DTU Physics) and Department of Micro- and Nanotechnology (DTU Nanotech). DTU Physics has a long experience of 57Fe Mössbauer spectroscopy and their expertise, and the main focus is on studying magnetic properties of nanoparticles. Within this laboratory, Mössbauer spectra can be acquired at temperatures from 6 K and up to just above room temperature and with applied magnetic fields of up to 6 T. This allows for phase identification and measurement of magnetic properties such as superparamagnetic blocking temperature, magnetic anisotropy, and magnetic moment of nanoparticles. DTU Nanotech represents a cross-disciplinary research environment where micro and nanotechnology are applied to a wide range of scientific disciplines, e.g. mechanics, optics, chemistry, medical technologies, and biotechnology. DTU Nanotech has access to state-of-the-art clean room facilities as well as advanced laboratories for physical and biochemical measurements. The Magnetic Systems group has expertise in the magnetic properties of nanoparticles, in the design and fabrication of magnetoresistive sensors, their integration in microfluidic systems, their use for on-chip measurements of Brownian relaxation of magnetic beads and their application for biodetection. Moreover, the group has general expertise in magnetism, lab-on-a-chip systems, application of magnetic beads and is also exploring a number of alternative on-chip biodetection read-out methods based on magnetic beads, e.g. by optical means.

Role(s) in the NanoMag project

The groups will take part in WP1 defining desirable properties of magnetic nanoparticles and will as part of WP4 characterise about 10 selected magnetic nanoparticle samples by Mössbauer spectroscopy. On-chip Brownian relaxation measurements and on-chip volume-based bioassays will be performed in WP6 (where DTU is also WP leader). Optimum assay strategies will be sought in a chip-based system with a Brownian relaxation read-out based on magnetoresistive sensor technology and/or a newly developed optical sensor technology.

MICROMOD PARTIKELTECHNOLOGIE GMBH (MICROMOD)

Description of organisation

Since 1995 Micromod has specialized in nanomaterial sciences and is manufacturing a large assortment of nano- and microparticles with functional properties (biochemical, magnetic, fluorescent) for research institutions and applicants in Life Sciences industry, predominantly producers of diagnostic kits and biotechnology companies. Within contract development projects Micromod supports several medical applications with customized magnetic nanoparticle systems. (http://www.micromod.de). Micromod’s scientific staff possesses a comprehensive expertise in the development and production of magnetic multicore nanoparticles as contrast agents in MRI and MPI, as nanocarriers for hyperthermia with alternating magnetic fields as well as for applications in biosensors, immunoassays, lab-on-chip devices and in high throughput nucleic acid separation. All development and production activities are regulated by ISO 9001 and 13485 quality management systems. The particle production can be performed under GMP conditions. Micromod has access to standard laboratories as well as to controlled areas: in-vitro diagnostics laboratory and a clean room tract, equipped with various synthesis and analysis devices.

Role(s) in the NanoMag project

Micromod will be mainly involved into the selection and synthesis of magnetic multicore particles (WP1, WP3). An optimization of synthesis concepts will be made with regard to standardization (WP5) as well as application and benchmarking (WP6).

NANOPET PHARMA GMBH (NANOPET)

Description of organisation

NanoPET undertakes own research and development on contrast agents and tracers for molecular and cellspecific imaging. Based on about 12 years R&D experience in pharmaceutical industry (Schering AG, now Bayer Healthcare) nanoPET has generated profound expertise in the field of in vivo imaging in all relevant imaging modalities and produces the first comprehensive portfolio of preclinical imaging agents. The multidisciplinary team has a strong background in the field of nanotechnology and exhibits a long standing experience on magnetic nanoparticles for pharmaceutical and other applications. The facility of nanoPET offers approx. 1000 m2 lab- & office-space with the acquired technical equipment and environment close to the Charité (Berlin Mitte), the Siemens Imaging Center and Bayer Healthcare. The implementation of a GMP facility is ongoing.

Role(s) in the NanoMag project

Nanopet will synthetize magnetic nanoparticle systems (both single and multi-core particle systems) and carry out DLS and z-potential measurements of the investigated nanoparticle systems.

NPL MANAGEMENT LIMITED (NPL)

Description of organisation

The National Physical Laboratory (‘NPL’) is the United Kingdom's national standards laboratory (since 1900), an independent centre of excellence in research, development and knowledge transfer in measurement and materials science. For more than a century NPL has developed and maintained the nation's primary measurement standards designed to ensure accuracy, consistency and innovation in physical measurement. NPL is the largest applied physics organization in the UK with more than 600 employees. The Quantum Detection team (QD) has a main research interest in precision metrology, especially nanoscale and quantum-based phenomena. The QD has a strong, long-term expertise in nanomagnetism, magnetic and semiconducting devices, microwave components and instrumentation, low-noise signal recovery, and scanningprobe microscopy in several forms. The group has a very strong experience in application of nano-SQUID sensors to metrological applications and, in particular to detection of ultra-small magnetic moments, down to ~ 104 μB. In all research directions QD goals are closely adjusted to stakeholders needs and requests. The team has a longstanding active collaboration and a number of research projects with leading European research groups in the area of single magnetic particle detection and nano-SQUID sensors for various applications.

Role(s) in the NanoMag project

NPL will work on standardization strategies and standardization methods for magnetic nanoparticle systems. NPL will also work with dissemination and exploitation activities (WP7) for instance set up contacts with industry, define the exploitation plan and work on training activities in the project. NPL is also WP leader of WP7.

PHYSIKALISCH-TECHNISCHE BUNDESANSTALT (PTB)

Description of organisation

The Physikalisch-Technische Bundesanstalt (PTB) is the national institute for science and technology and the highest technical authority of the Federal Republic of Germany for the field of metrology and safety engineering. PTB comes under the auspices of the Federal Ministry of Economics and Technology. It meets the requirements for calibration and testing laboratories as defined in the EN ISO/IEC 17025. It has a staff of about 1800 employees. It is fundamental task of PTB to realize and maintain the legal units in compliance with the International System of Units (SI) and to disseminate them, above all within the framework of legal and industrial metrology. The department of ‘Biosignals’ of PTB, which is involved in this project, is internationally leading in the metrology of MNPs in medical applications. For the magnetic detection of nanoparticles, the department of Biosignals is equipped with several SQUID measurement systems, most of them operated in magnetically shielded rooms. Two set-ups were designed and are used for single channel SQUID magnetorelaxometry (MRX) measurements for the characterization of MNP properties. In addition, the department of Biosignals operates a variety of devices for the characterization of MNP, including magnetic susceptometry, magnetic particle spectroscopy, and magnetic particle imaging. The department of biosignals consists of more than thirty senior scientists, postdocs, postgraduate and undergraduate students, and technical staff, one third of which is working in the field of magnetic nanoparticle characterization. Over the last 15 years, the MRX group of the Biosignal department has consisted of up to 10 scientists, engineers, and students, most of which were funded by national and international grants. During this time, a lot of expertise concerning the characterization of MNPs and the functionalisation qualities of nanoparticles by means of MRX has been collected. More recently, SQUID measurement technology was employed for determining the biodistribution of MNPs in animal models. These studies are documented by more than thirty publications in peer-reviewed journals. At PTB, the consortium partners will have access to state-of-the-art magnetically shielded rooms and SQUID multi-channel-reference devices, which provide worldwide unique magnetic measurement conditions.

Role(s) in the NanoMag project

PTB will work on standardization strategies, define standardization methods and analysis and definition of the standardization roadmap. PTB will also carry out magnetization measurements, magnetic modelling and magnetorelaxometry (magnetization vs. time) of the studied magnetic nanoparticle systems in the project. PTB is also WP leader of WP4 and WP5.

SOLVE RESEARCH & CONSULTANCY AB (SOLVE)

Description of organisation

SOLVE Research and Consultancy AB is based in Lund, Sweden and specializes in the investigation of natural, biological and synthetic nanomaterials with respect to their physicochemical properties, aggregation state and complex formations. SOL E integrates the separation technique field‐flow fractionation (FFF) as a core technology into its characterization approach because nanomaterials are inherently polydisperse and it is critical to parse them into discrete populations prior to characterization to better ascertain structure-property-performance relationships. SOLVE is comprised of scientists with diversified expertise in nanoparticles, surface and colloid chemistry, emulsions and foams, functional foods, polymers, proteins, separation and characterization methods, light scattering, membranes and in vitro studies.

Role(s) in the NanoMag project

SOLVE will contribute through the development and application of separation and characterization methods for MNPs utilizing asymmetrical flow field-flow fractionation and/or sedimentation field-flow fractionation. These systems are connected in-line with multi-angle light scattering and concentration based detectors to probe the MNP properties such as size, shape, density, surface chemistry or load, aggregation state or complex formations. Fraction collection is easy for additional off-line characterization or to provide monodisperse nanoparticle samples to other collaborators. SOLVE can also contribute by providing studies of MNP behaviour in various environments. The FFF method allows for the fractionation of nanoparticles in a variety of environments such as high and low pH, different salts and concentrations, and solutions which mimic conditions in the body or the environment.

SP SVERIGES TEKNISKA FORSKNINGSINSTITUT AB (SP)

Description of organization

SP Sveriges Tekniska Forskningsinstitut AB (SP Technical Research Institute of Sweden AB) is owned by RISE Research Institutes of Sweden Holding AB under the Ministry of Finance. SP is the national institute for technical evaluation, research, testing, certification, metrology and calibration and is working closely with large and small companies, universities, institutes of technology and other organizations. SP consists of eight technical units and six subsidiary companies covering a wide technical range. SP, the parent company has some 1200 co-workers and bases the services on competence, efficiency, impartiality and international acceptance. SP's headquarters are located in Borås, Sweden. R&D in the form of consortium projects, several EU funded projects (FP 7) and confidential contract assignments with industries are carried out. The unit SP Chemistry, Materials and Surfaces (SP KM) conducts research, testing and certification in a wide range of areas related to analytical chemistry and materials technology. Core competences include synthesis of nanostructured materials, surface modification and organic and inorganic analyses of major and trace components in gases, liquids and solids, physical and chemical characterization of materials, surfaces and interfaces, and testing and prediction of material performance and durability in different environments and applications. Important application areas include environmental technology, nanotechnology, coatings, emulsions for pharma and consumer products, biodegradable materials, and materials for renewable energy, medical technology, and polymeric materials. SP KM is currently involved in several European projects and as the coordination role for 5 EU projects funded by FP7 where several types of inorganic and magnetic nanoparticles with different surface modifications and properties are being developed for their use in commercial products.

Role(s) in the NanoMag project

SP will carry out work on standardization strategies and definition of the standardization roadmap. SP will also carry out particle synthesis and particle surface functionalization. SP is also WP1 leader.

SWEDISH ICT RESEARCH AB (Swedish ICT)

Description of organisation

Swedish ICT performs applied research, knowledge creation and innovation in both specific application areas and the generic platforms. Swedish ICT role is to offer and provide solutions to existing and future needs based on ICT research. Together with partners, customers and users, solutions are developed as new services and products. In many cases the potential of new services and technologies are demonstrated in direct collaboration with our industrial partners or through testbeds and demonstrators, and in cases where the information is open in symposiums and direct outreach activities. The most important general result of our activities is that time to market, from research and development to product launch, is shortened for industry. Start of a new business is another way to create renewal of industry and society based on ICT, for which Swedish ICT has a successful process. For the public sector, it means a wider range of new services and new technologies with potential application for improved efficiency.

Role(s) in the NanoMag project

Swedish ICT will be the Project Coordinator of the NanoMag project. The work includes administrative and financial management of the project. Swedish is WP leader for WP8.

TECHNISCHE UNIVERSITAET BRAUNSCHWEIG (TUBS)

Description of organisation

The Technical University Carolo-Wilhelmina Braunschweig is one of the largest universities in Lower Saxony in Germany with a total of about 12.000 students. It consists of six faculties. The Institute of Electrical Measurement and Fundamental Electrical Engineering belongs to the Department of Electrical Engineering, Information Technology, Physics. The Institute of Electrical Measurement and Fundamental Electrical Engineering has a wide field of research activities ranging from the fabrication of thin-film devices to the development of complete measurement systems. These systems are mainly focussed on applications in biomedicine and biochemistry and realized together with clinics and industry. In the last years, the research focus was put on the characterization and application of magnetic core-shell nanoparticles (NPs) in medicine and bioanalytics. For the comprehensive characterization of the magnetic NPs, a variety of magnetic techniques has been developed and established: the magnetorelaxometry technique with sensitive fluxgate magnetometers, the ac susceptibility technique for frequencies from a few 10 Hz up to 1 MHz, the magnetic particle spectroscopy (MPS) and a fluxgate-based setup for the study of magnetic nanoparticles in rotating magnetic fields. Along with the techniques, sophisticated theoretical models were developed to derive NP parameters from the analysis of the measurement results. The same techniques were also utilized for the realization of homogeneous binding assays.

Role(s) in the NanoMag project

TUBS will carry out magnetorelaxometry (magnetization vs. time), magnetic modelling, AC susceptometry (magnetic susceptibility vs. frequency), magnetic particle rotation measurements and magnetic particle spectroscopy, of the magnetic nanoparticle systems. TUBS is also WP leader of WP2.

TECHNISCHE UNIVERSITEIT EINDHOVEN (TUE)

Description of organisation

Eindhoven University of Technology is a leading university of technology with a strong focus on health, in which our research is gaining a worldwide reputation. More than 250 researchers from different departments are working together in this area to develop advanced technology applications. Key topics include molecular imaging, regenerative medicine, systems biology, biosensors and chemical biology. Groups active in these fields are united in the Institute for Complex Molecular Systems (www.tue.nl/icms). TU/e’s traditionally strong links with industry and healthcare enable the University to translate research into tangible new products and services. The research group Molecular Biosensors for Medical Diagnostics (MBx) of the Department of Applied Physics at the Eindhoven University of Technology investigates novel technologies for high performance biomolecular assays based on particles and integration (see www.phys.tue.nl/mbx). The aim is to demonstrate technology components for the detection of proteins, nucleic acids, and cells, that have a potential to revolutionize performance in terms of sensitivity, specificity, speed, accuracy, robustness, and cost-effectiveness. The group focuses on molecular and cellular bio-nano studies using micro- and nano-particles, with emphasis on single-particle, single-molecule and single-cell studies. The particles can be seen as agents that make an interface between on the one hand the molecular-scale processes with biomolecular specificity, and on the other hand the device-scale processes such as actuation and detection which enable control and read-out of integrated assays.

Role(s) in the NanoMag project

The biosensor group (MBx) of TUE will contribute to the definition of the requirements for multicore magnetic particles that can apply torque on e.g. protein systems. The characterization of the overall torque of the multicore particles will be performed at various angular field frequencies. The performance of the magnetic particles in applications will be demonstrated in WP6.

UNIVERSIDAD DE CANTABRIA (UC)

Description of organisation

The University of Cantabria's (UC) scientific activity maintains a balance between basic and applied research. The first type of activity is mainly financed through public funds (principally the National R&D Plan and the European Union Framework Programme). In the last five years, researchers at the University of Cantabria have executed 423 projects of this kind, with a budget amounting to over 36 million euros. In the same period, the R&D groups have carried out a further 1,403 projects mainly with companies has overall financing amount to 61,9 million euros. Academically, the balanced ratio of students (12,228) to teaching staff (1,202) favours the quality of both teaching and individual attention through guidance and support services. Overall, it has been granted a Campus of Excellence within Spain University system and it stands around the Top-15 Research Institutions (relative) in Spain.

Subgroup of Materials Magnetism at the Departamento CITIMAC: The Department Ciencias de La Tierra y Física de la Materia Condensada (CITIMAC) is an academic unit involving groups of Geology and Environmental Science and Condensed Matter Physics. Within the Condensed Matter Physics, there are two experimental groups and two theoretical groups. One of the experimental groups (High- Pressure and Spectroscopy) is led by Prof. F. Rodriguez (Vice-president of the world AIRAPT). A theoretical group is led by Prof. M. Moreno and the remaining group led by Dr. J. Junquera (in the core of the SIESTA group, for first-principles calculations). Including our group there are 15 permanent staff. The group of magnetism has been developing its activity since early 80s, with a slow staff increase, reaching an approximate number of 300 publications. The group has regularly got financial support from the Spanish National Research Agency apart from UE support, mainly for equipment. Nowadays we form a compact group with 4 permanent, 1 post-doc, 1 technician and 3 Ph D students. Our interest is focused on the basic interaction of magnetic compounds. During the last years a strong output has been concentrated of the analysis of magnetic interparticle interactions of 3d- and 4f-nanomagnets in bulk (milled), chemically produced (reduction) and thinfilms. All this work has been performed in close relation (our national project is coordinated with University of Oviedo, ICMA-CSIC Zaragoza and U. Basque Country) with the groups led by Dr. P. Gorria in Oviedo, Prof. M. L. Fdez-Gubieda, Bilbao and Dr. J. Chaboy (CSIC-ICMA). We count with a complete set of instruments including: XRD (temperature chambers), QD-PPMS (AC-susceptibility, DC-magnetisation, specific heat, thermopower and resistivity), QD-MPMS (AC, DC, low-field + RSO head) and Dr. L. Fernández Barquín is also the scientific leader of the TEM 200 kV (General Service). We have a deep and successful contact with Large Facilities across Europe of neutron scattering, muon relaxation and Synchrotron. Regular access to Inst. Laue-Langevin, RAL-ISIS, LLB, PSI, among others, has been achieved by our team. In fact, there is a personal contact with some key scientists in these Large Facilities. The interpretation of a necessary combination of experimental results of macro- and microscopic origin is a distinctive asset of the group at UC.

Role(s) in the NanoMag project

UC will carry out general AC-susceptibility and DC-magnetisation (including pressure cell analysis). UC have access to SAXS and SANS instruments at large facilities. UC will also carry out neutron characterization of magnetic structures of the nanoparticle core/shell. UC can give support (when needed) for TEM analysis and routine characterization by XRD. UC will also have large responsibilities in the dissemination and exploitation WP (WP7).

UNIVERSITY COLLEGE LONDON (UCL)

Description of organisation

UCL is one of Europe’s leading health research multidisciplinary universities and is one of the largest and most productive centres of Biomedical Science in the EU. It has a long track record of successful participation in EU projects, and is currently participating in more than 200 FP7 projects with a total research budget of approximately Eur. 100 million. The Institute of Biomedical Engineering (IBME) at UCL was established in 2011 with the central mission of delivering impact on medical technology, on patient benefit, and on healthcare policy. It represents a cohesive inter-connected community of 150 permanent academic staff – biomedical scientists and engineers, medical physicists, and clinicians – and was created to instil in that community a culture of enterprise and innovation in order that the translation of research outcomes into clinical adoption and patient benefit becomes a reality. IB E’s strategy for facilitating impact through innovative medicine is focused on offering timely practical advice and support to staff engaged on early-stage research with significant translational potential. The strategy is based on a recognition that maximising the success of translation requires a holistic approach and support at all stages of the innovation cycle from clinical need identification, ideation, proof of concept, clinical trials, commercialisation, implementation, health economics and adoption.

Role(s) in the NanoMag project

UCL will carry out SQUID-VSM DC magnetization measurements (including Henkel plots and FORC curves), highfrequency AC susceptibility measurements, magnetic hyperthermia analysis, A4F fractionation and 57Fe Mössbauer spectroscopy.

UPPSALA UNIVERSITET (UU)

Description of organisation

The magnetism group at the department of Engineering sciences has almost twenty years of experience working with magnetic nanoparticle systems. The group has built up expertise relating to fundamental properties of interacting as well as non-interacting nanoparticle ensembles. During the last 5-10 years the group has widened the activities to include applications of magnetic nanoparticles in biotechnology. The infrastructure includes experimental setups for DC magnetization, magnetic relaxation, AC susceptometry, magnetic noise and ferromagnetic resonance (FMR) measurements.

Role(s) in the NanoMag project

UU will carry out temperature (ZFC and FC), field (magnetization curves at different temperatures) and time dependent magnetization measurements, temperature and frequency dependent AC susceptibility measurements (χ(f,T)) and Ferromagnetic resonance measurements. UU will also work in the dissemination and exploitation WP (WP7).

UNIVERSITAET ZU LUEBECK (UZL)

Description of organization

The University of Lübeck comprises the Sections of Informatics/Technology and Natural Sciences and the Section of Medicine affiliated with a teaching hospital. The Institute of Medical Engineering (www.imt.uni-luebeck.de) is part of the Section of Informatics/Technology. The research interests of the team at the Institute of Medical Engineering are in physical sensing and image acquisition techniques as well as image computing and system modelling in biophysical, medical and technical applications. The key competence covers the area of medical and technical imaging using tomographic techniques. This includes the development of reconstruction algorithms, signal pre- and post-processing methods, and front-end electronics. The institute is working on four instrumentation projects in the field of magnetic particle imaging (MPI). The research group started to work on MPI in 2007 and was the first to demonstrate the feasibility of a new single-sided MPI scanner geometry. Further research activities are MPI based on the field-free line (FFL) concept, magnetic particle spectroscopy (MPS), simulation studies and efficient reconstruction for MPI.

Role(s) in the NanoMag project

UZL will carry out magnetic particle spectroscopy and magnetic particle imaging of the magnetic nanoparticle systems.

Project Partners

Project partners

     

This project has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 604448