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Work packages »
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Work packages
WP1
In WP1 we will define the magnetic nanoparticle systems that will be later synthesized (WP3) and analysed (WP4) in the project. We will also decide the additional commercial magnetic nanoparticle systems that will be analysed.
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Definitions of the magnetic nanoparticles (MNPs) that will be manufactured and analysed in the project (single-core and multi-core particles, surface chemistry on the particle surfaces, etc will be addressed). We will decide which material, surface chemistry, bio-functionality on the particle surface and particle sizes (core size and total particle size) for both single-core and multi core particles that will be studied.
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Definitions of commercial magnetic nanoparticles that will be additionally analysed in the project. We will study both commercial nanoparticles from NanoMag partners as well as from other external companies that are widely used in different biomedical applications. To ensure a representative set of commercial nanoparticles we will select MNPs from key applications including industrial, pharmaceutical or medical applications as well as particles from material providers. We will discuss the nanoparticle systems with our industrial partner network that we will start to build up in Month 1 in WP7 (dissemination).
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Magnetic stability, colloidal stability and clustering effects of both the single-core and multi-core particles will be addressed.
WP2
The different types of magnetic nanoparticle systems that we have defined in WP1 will be analysed by various techniques in WP4. In this WP2, we will define and investigate the various analysis techniques and decide which of the techniques will be used for the respective magnetic nanoparticle system and which nanoparticle parameters are important for the standardization work in WP5. We will also address which magnetic and structural models will be used in order to determine relevant parameters for a deeper understanding of the properties of the magnetic nanoparticles. This will be crucial for the work in both WP4 and WP5. Initial characterization and analysis work on commercial magnetic nanoparticles will also be carried out. We will classify the analysis techniques according to standard methods (used on all of the samples) and more advanced analysis methods (used on a fewer number of samples). The two classes of analysis methods will be defined by their strengths and weakness regarding determining magnetic nanoparticle properties. The suggested analysis standardization methods will be defined during the work in WP4 and WP5. In the month 12 review we will have a draft outline which characterization/analysis methods that shall be used in standardization of magnetic nanoparticles.
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Definitions of analysis techniques and models that will be used in connection to each characterization method for respective magnetic nanoparticle type.
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Analysis of the first initial characterization results of commercial magnetic nanoparticle systems.
WP3
In this WP we will synthesise magnetic single-core and multi-core particles with special magnetic, chemical and structural properties according to the definitions in WP1 and that will be used in the analysis techniques in WP4 in order to define the analysis standard techniques in the standardization method work in WP5. We will also use commercial magnetic nanoparticles that can be compared with the new synthesized magnetic nanoparticles. The manufactured magnetic nanoparticle systems will already in this WP be analysed with basic and routine characterisation methods in order to find out that the right particle properties has been obtained.
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Synthesis of single-core magnetic nanoparticles with special magnetic, chemical, material and structural properties. Results from basic and routine analysis techniques.
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Synthesis of multi-core particles with special magnetic, chemical and core configurations, which will be used in the project. Results from basic and routine analysis techniques.
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The new nanomaterials will be compared with commercial magnetic nanoparticle system.
WP4
In WP4 we will carry out the characterization and analysis work that we have defined in WP2. We will use models in order extract the relevant parameters from respective analysis results. All of the used analysis methods and models are described in detail in the introduction part in this application. The results in this WP will be further used in the standardization work in WP5. We will classify the analysis techniques according to standard methods (that shall be used on all of the samples) and more specialized analysis methods (used on a fewer number of samples). The two classes of analysis methods will be defined by their strengths and weakness regarding determining different magnetic nanoparticle properties. The specialized stage will hold analysis techniques which will give extra details connected with specific scientific and high-tech outputs. At the month 12 review we will have a deliverable that describes the classification of analysis methods.
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Characterization and analysis methods will be used on the synthesized magnetic nanoparticle systems in WP3. The characterization methods are based on basic analysis methods and new application oriented techniques. The application methods are somewhat directed to biomedical applications but can also be used to studying the properties of the magnetic particles.
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Characterization and analysis methods on commercial magnetic nanoparticle systems and comparison of the results with the new synthesized nanomaterials.
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The following analysis and modelling methods will be used. Basic analysis methods according to; Magnetization (DC) versus field and temperature, Zero field cooled and field cooled, in and out-of-phase AC susceptibility measurements, Mössbauer Spectroscopy, X-ray, Transmisson Electron Microscopy, High Resolution Electron Microscopy, Scanning Electron Microscopy, Medium and high frequency susceptometry, Dynamic Light Scattering and zeta-potential, Ferromagnetic Resonance, Asymmetrical flow field flow fractionation, Neutron Scattering, Magnetic Modeling, Asymmetrical flow field flow fractionation and Mass Spectrometry. We will also use more application oriented methods on specific nanoparticle systems, such as; Magnetorelaxometry, Magnetic particle spectroscopy, Magnetic particle rotation, Magnetic separation, NMR R1 and R2 relaxivities and Magnetic hyperthermia measurements.
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Correlate the results in order to get a self-consistent picture of the magnetic nanoparticle systems. For instance by using complementary analysis methods to find out for instance effects of magnetic dead layers in the magnetic core, how the magnetic anisotropy vary with particle size and the magnetization reversal for larger single-core magnetic nanoparticles, etc.
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We are aiming at a strong feedback from WP3 and a connection to WP5 to define the relative importance of every technique for the standardization.
WP5
In this WP5 we will go through all the results from the synthesis work in WP3 and the results from the characterization and analysis work in WP4 and define standardization methods and parameters for magnetic nanoparticle systems. We will use the results from both the new synthesized magnetic nanoparticles and the commercial magnetic nanoparticle systems. In WP4 we will classify the analysis techniques according to standard methods and more specialized analysis methods. The two classes of analysis methods will be defined by their strengths and weakness regarding determining different magnetic nanoparticle properties. The classification of the analysis methods will help us in the standardization work in order to find out analysis methods that must be done and other more specialized methods to be used in specific applications. In the NanoMag consortium we have the metrology institutions NPL, PTB, BAM and SP that carry out outstanding research on magnetic nanostructures, general nanostructures and their applications and they are involved in WP5.
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Define standardization strategies using all of the synthesis and analysis results.
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Define a standardization plan for different magnetic nanoparticle systems.
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Define the characterization and analysis methods and relevant parameters from the analysis that shall be used as standardization of the magnetic nanoparticle systems.
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Define a roadmap on exploitation and commercialization of main metrological results.
WP6
In this WP we will investigate whether the synthesized, analyzed and standardized magnetic particle systems improve the performance of our more application oriented analysis techniques. We will show that it is possible to tailor the optimum magnetic nanoparticle systems for the chosen techniques and follow our standardization methods defined in WP5 to traceability of the properties all the way from the synthesis work in WP3 to the result from the specific applications. This will prove a benchmark and show that it will be possible to plan for an optimum design, synthesize the nanoparticles thereafter with the desired specifications.
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Choose three of our application oriented analysis techniques (Brownian relaxation measurement, Magnetic particle rotation and Magnetic particle imaging) and define the optimum nanoparticle properties for respective application.
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Choose synthetized optimum nanoparticles for the respective application and show the results of the measurements and analysis and determine if the application result where optimum from a magnetic nanoparticle view.
WP7
The objectives of this WP are:
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Provide scientific dissemination in terms of peer-reviewed publications, participation in the relevant conferences linked to the nanoparticle synthesis and analysis methods and standardization analysis.
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Exploitation plan development and implementation with user, industry, regulatory and standards bodies of relevance to the international nanoparticles area and national measurement communities.
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We will contact relevant industrial partners to ensure take-up of the result from the NanoMag project. The business areas of the chosen industrial partners will be from medical/bio areas as well as to more process industrial oriented areas.
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Industrial dissemination in terms of a best practice guide for fabrication, structural and magnetic characterization of magnetic nanoparticles suitable for various applications in biomedicine. Recommendations to industry, SMEs and research groups for the use of novel techniques and methods appearing in the magnetic nanoparticle field.
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Guarantee the impact of NanoMag through the creation of a comprehensive exploitation plan with identified stakeholders and other sectors.
WP8
The objectives of the management WP are:
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Establish good communication between EU and the NanoMag Consortium
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Preparation of periodic and final reports
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Ensure first-class Administrative and Financial Management and timely reporting
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